Stuck in the labyrinthine Care Center? You need answers, not a lecture. Here are all the safe combinations and puzzle box solutions required to escape, listed in the order you'll likely encounter them. No filler, just the codes.
- Bar & Lounge Safe: 10 (Clockwise) → 80 (Counter-Clockwise) → 30 (Clockwise)
- Chairman's Office Puzzle Box: Moon → Sun → Star → Moon
- Examination Room Safe: 30 (Counter-Clockwise) → 10 (Clockwise) → 50 (Counter-Clockwise)
- Organ Transport Box: Dial to 'Hand' → Press Buttons '2' and '5' → Move Right Switch to Center → Dial to 'Auto'
- Lead Researcher's Office Puzzle Box: Star → Sun → Moon → Sun
- Security Manager's Office Puzzle Box: Contextual; solved by inspecting the manager's notebook first.
The Dial Safes: Unlocking the West and East Wings
The Care Center contains two traditional dial safes, both of which hold valuable Antique Coins. Cracking them is essential for acquiring upgrades and key items from the Parlor's reward cases. Both require precise inputs, turning the dial left and right until the tumbler clicks into place.
Bar & Lounge Safe (West Wing)
Located on the second floor of the West Wing, behind the bar in the appropriately named Bar & Lounge, this safe is an early prize. You'll need to sneak past or eliminate a few zombies, including one of the two formidable Singer zombies required for the 'Deadly Duet' challenge. The area is cramped, so be prepared.
The combination is found on a file in the main Office much later, but you don't need it to open the safe. Input the code as soon as you arrive to claim your reward.
- Location: Behind the counter in the Bar & Lounge, West Wing 2F.
- Combination: Spin the dial Clockwise to 10, then Counter-Clockwise to 80, and finally Clockwise to 30.
- Reward: 3 Antique Coins.
Resident Evil Requiem in-game screenshot
Examination Room Safe (East Wing)
Deep in the East Wing, the Examination Room safe holds another stash of coins. You'll find the file containing this combination in the changing room just before the Conference Room, but like the first safe, you can bypass the scavenger hunt if you know the code beforehand. The room is initially quiet, but can become a hotspot for zombies, so work quickly.
- Location: In the Examination Room, East Wing 1F.
- Combination: Spin the dial Counter-Clockwise to 30, then Clockwise to 10, and finally Counter-Clockwise to 50.
- Reward: 3 Antique Coins.
The Puzzle Boxes: Symbols of Power
Three major puzzle boxes block your path through the Care Center's executive and research areas. Each requires a specific sequence of four symbols to be pressed, rewarding you with a Quartz key item needed to unlock the main hall's ornate door or other critical items.
Chairman's Office Puzzle Box (West Wing)
After navigating the Gallery, you'll enter the Chairman's Office suite. The puzzle box sits on a table in the antechamber, near a file titled 'Copy of an Email to a Manager'. A zombified chairman slumps in his chair in the adjacent office, so be cautious. The solution is hinted at in the 'Chairman's Note' file, which you can reveal by using the Pencil on the notepad on the coffee table. Or, you can just input the sequence directly.
- Location: Antechamber of the Chairman's Office, West Wing 2F.
- Sequence: Moon → Sun → Star → Moon
- Reward: Moon Quartz.
Resident Evil Requiem in-game screenshot
Lead Researcher's Office Puzzle Box (East Wing)
This box is locked tight inside the Lead Researcher's inner office on the second floor of the East Wing. First, you'll need to acquire the Corrosive from the Conference Room after dealing with the second Singer zombie. Use the Corrosive on the lock to access the box. The solution is contained within 'Spencer's Research 1', a file found inside a leatherbound notebook right next to the box itself.
- Location: Inner office of the Lead Researcher's Office, East Wing 2F.
- Prerequisite: Use the Corrosive item on the box's lock.
- Sequence: Star → Sun → Moon → Sun
- Reward: Sun Quartz and the 'Leatherbound Notebook' file.
Security Manager's Office Puzzle Box (East Wing)
This final puzzle box, found in the Isolation Ward, is less about a code and more about situational awareness. It doesn't have a fixed combination you can find written on a file. Instead, interacting with it after reading the nearby 'Security Manager's notebook' will trigger the solution. It’s a contextual unlock designed to catch you off guard, as solving it also triggers a cutscene and releases a fresh wave of dangerous zombies from the isolation cells. Be ready for a fight immediately after you claim your prize.
- Location: Security Manager's Office, past the Isolation Ward, East Wing B1.
- Solution: First, inspect the Security Manager's notebook on the desk. Then, interact with the Puzzle Box.
- Reward: Level 3 ID Wristband.
Mechanical & Situational Puzzles
Not every lock uses a code or a symbol. A few unique obstacles in the Care Center require manipulating machinery or observing your surroundings to proceed.
The Organ Transport Box (Garage)
Down in the Garage, accessible from the Custodian's Office, you'll find a large medical transport container. The solution for opening it is found very late in the 'Unlocking the Organ Transport Box' file, but it can be solved on the spot with the correct inputs. This puzzle involves a dial, two numbered buttons, and a switch. Performing the actions in the right order will open the container and grant you a key component for the grotesque cadaver puzzle in the Examination Room.
- Location: At the far end of the Garage, West Wing B1.
- Solution Steps:
- Turn the main dial to the 'Hand' symbol.
- Press the buttons marked '2' and '5' so they are depressed.
- Move the switch on the right side of the box up to its center position.
- Turn the main dial back to the 'Auto' symbol.
- Reward: Artificial Lungs.
Resident Evil Requiem in-game screenshot
Internal Dispute Challenge
While not a puzzle to progress, this environmental challenge requires a puzzle-like solution. In the Records Room, accessible from the second-floor Office, you'll find two zombies: one attached to an I.V. stand and one untethered. To complete the 'Internal Dispute' challenge, you must provoke the I.V. zombie into striking the other one. The easiest method is to grab the Empty Bottle from the outer office, creep into the Records Room, and throw it at the wall behind the non-I.V. zombie. The noise will cause the I.V. zombie to swing its stand wildly, hitting its companion and ticking off the challenge.
- Location: Records Room, West Wing 2F.
- Solution: Throw an Empty Bottle to distract the I.V. zombie, causing it to attack the other zombie in the room.
- Reward: 'Internal Dispute' challenge completion.
Final Take
Solving the Care Center's collection of locks and puzzles is a test of memory and observation, but knowing the solutions ahead of time transforms it into a simple, efficient sweep. With these codes and sequences in hand, you can focus your attention on navigating the treacherous halls, managing your inventory, and surviving the horrors that await. Now go claim your rewards.