33 Immortals Best Perks Guide: The S-Tier Virtues, Sins, and Relics for Your First Win

The best perks in 33 Immortals are those that create powerful synergies between your chosen weapon, your Relic, and universal damage multipliers. This 33 Immortals best perks guide will show you that for most builds, focusing on stacking Wrath for critical damage, Pride for elite-killing power, and Gluttony for survivability provides the strongest foundation for any dive into damnation. Raw damage is king, but the right combination of utility and defense will carry you through the final battle.

Unlike other roguelikes where a single overpowered boon can define a run, success in 33 Immortals comes from layering complementary effects. A perk that adds a chain lightning effect is good; that same perk combined with another that increases attack speed and a third that makes shocked enemies vulnerable is a run-winner. This guide breaks down the top-tier perks that work for any build, specific synergies for each weapon type, and the crucial role your starting Relic plays in it all.

01

How Perks Work: A Primer on Virtues & Sinstag

In 33 Immortals, perks are called Boons, granted by various gods from the Olympian pantheon. These Boons are thematically categorized into the Seven Deadly Sins and Seven Heavenly Virtues. While you might expect Virtues to be purely defensive and Sins to be offensive, the system is more nuanced. For example, the Sin of Gluttony often provides lifesteal and health-related buffs, making it one of the best sources of survivability.

Boons come in several rarities, which you can identify by their color:

• Common (White)
• Rare (Blue)
• Epic (Purple)
• Heroic (Gold)

As a rule, you should almost always prioritize a higher-rarity Boon over a lower-rarity one, unless the lower-rarity option completes a critical synergy for your build. You'll acquire these Boons from chests after clearing enemy encounters, from Charon's shops, or as rewards for completing specific challenges within a run. The pool of Boons offered is influenced by your weapon and your starting Relic, but there's always a heavy dose of randomness.

02

The S-Tier Perks for Any Buildtag

While weapon-specific Boons are powerful, a core set of universal perks provides the raw stats and utility needed to survive the escalating chaos of a 33-player raid. These are the Boons you should almost always pick up, regardless of your chosen weapon or playstyle. They form the bedrock of a successful build.

Here are the must-have perks, categorized by their governing Sin or Virtue:

• Wrath (Critical Chance & Damage): Wrath is the undisputed king of damage scaling. Because it multiplies your base damage, its value only increases as your run progresses. Any Boon that increases your critical strike chance or, more importantly, your critical damage modifier is an instant pick. Look for Heart-Piercing Strike (flat crit damage boost) and Seething Hate (gain crit chance after a dash).
• Pride (Elite & Boss Damage): The most dangerous enemies in 33 Immortals are the elites and the final bosses. Perks under the Pride category offer massive, conditional damage boosts against these specific threats. Arrogant Soul (+% damage to enemies with over 75% health) is fantastic for bursting down fresh targets, while Crown of Hubris (flat % damage increase to bosses) is essential for the final encounter.
• Gluttony (Survivability & Lifesteal): You can't deal damage if you're dead. Gluttony perks are the primary source of in-combat healing. Insatiable Hunger (a small percentage of all damage dealt is returned as health) is the single best survivability perk in the game. It turns aggressive offense into a powerful defense, especially when paired with fast-hitting weapons.
• Lust (Attack Speed & Chain Effects): More attacks mean more chances to proc other effects, like critical hits or status ailments. Lust perks, like Frenzied Desires, provide straightforward attack speed boosts that benefit every weapon. This category also includes powerful chain effects, such as a chance for your attacks to create chain lightning, which is invaluable for clearing large mobs of weaker enemies.
• Diligence (Cooldown Reduction & Resource Gain): Your weapon's Special and your Relic's active ability are often your most powerful tools. Diligence perks reduce their cooldowns, allowing for more frequent use. Boons like Tireless Labor can fundamentally change your combat rhythm, turning a long-cooldown ultimate into a regular part of your rotation.

03

Top-Tier Perks for Specific Weapon Archetypestag

Once you have a solid foundation of universal perks, you can start specializing. Each of the four weapon archetypes has unique strengths that can be amplified dramatically by the right set of Boons. The goal is to find perks that enhance what your weapon already does best.

For Bows (Artemis's Kiss)tag

Bows are all about safe, ranged damage and landing powerful charged shots. Your perk strategy should focus on amplifying that single-shot damage and improving your mobility.

• Best Synergy: Wrath + Pride. You want every arrow to hit like a truck. Stack critical damage (Wrath) and elite damage (Pride) to one-shot dangerous enemies from a distance. A charged critical headshot buffed by Pride perks can often delete an elite enemy before it can even act.
• Must-Have Perk: Eagle Eye. This is a bow-specific Boon that dramatically increases the damage of your charged shots the farther the arrow travels. It rewards precise positioning and makes you a devastating sniper.

For Swords (Stygian Blade)tag

Swords excel at close-quarters combat, dealing wide, sweeping arcs of damage to multiple foes. Survivability and attack speed are your primary concerns.

• Best Synergy: Gluttony + Lust. You need to stay healthy while in the thick of the fight, making Gluttony's lifesteal perks non-negotiable. Combine this with Lust's attack speed boosts to increase your damage output and, by extension, your healing from lifesteal.
• Must-Have Perk: Vampiric Steel. A sword-specific perk that grants a significant lifesteal bonus specifically to your primary combo attack, turning your main damage source into your main survival tool.

For Spellbooks (Grimoire of Thoth)tag

Spellbooks are masters of area-of-effect (AoE) damage and applying status effects. Your goal is to blanket the entire screen in damaging fields.

• Best Synergy: Sloth + Diligence. Many Spellbook abilities apply Damage-over-Time (DoT) effects, which fall under the Sloth category. Enhancing the duration and damage of these DoTs is key. Diligence is crucial for reducing the cooldown of your high-impact spell abilities, ensuring you have maximum uptime on your AoE fields.
• Must-Have Perk: Lingering Plague. This perk causes enemies defeated while under the effect of your DoT to explode, spreading the effect to nearby enemies. It's the key to starting a chain reaction that can wipe out entire waves.

For Bracers (Aegis of Olympus)tag

Bracers are a unique hybrid, offering rapid-fire punches up close and a powerful defensive block. They reward an aggressive, in-your-face playstyle.

• Best Synergy: Lust + Envy. The bracers' rapid attacks make them perfect for stacking on-hit effects. Lust perks that add a chance for chain lightning or other procs on every hit are incredibly effective. Envy perks, which often deal retaliatory damage or apply debuffs when you're hit, synergize well with your desire to be in the middle of the fray.
• Must-Have Perk: Thunderous Fists. This Boon gives your punches a chance to create a small lightning nova on impact. With the bracers' attack speed, this triggers almost constantly, providing immense crowd control and AoE damage.

04

Don't Sleep On These Relicstag

Your starting Relic is the first and most important choice you make in a run. It provides a powerful active ability and often pushes the Boons you're offered in a certain direction. Choosing a Relic that complements your intended build is critical.

• Feather of Hermes: Grants an extra dash charge and a speed boost. This is the ultimate defensive and repositioning tool, perfect for ranged builds like the Bow that need to maintain distance. It allows you to be more aggressive with your positioning, knowing you have an escape.
• Charon's Obol: Starts you with extra gold and increases all gold gains. This is an economy-focused Relic. Picking it allows you to buy more Boons, healing, and upgrades from shops throughout your run. It's a high-risk, high-reward choice that can pay off if you survive the difficult early stages.
• Cursed Chalice: Significantly boosts your damage but constantly drains your health, which can only be recovered through lifesteal or pickups. This is the ultimate glass-cannon Relic, forcing you to build into Gluttony perks to survive. When paired with a sword and lifesteal Boons, it creates an incredibly powerful, self-sustaining brawler build.

05

Understanding Ascension Perks: Your Permanent Upgradestag

Not all progress is lost when you die. After each run, you'll earn Hope, a currency you can spend on permanent upgrades at the Tree of Immortality in the game's hub area. These "Ascension Perks" provide small but crucial bonuses that make subsequent runs easier.

Prioritizing the right upgrades can significantly speed up your progression. Here's what to focus on first:

1. Death Defiance: The most important upgrade. This allows you to revive once per run after taking fatal damage, giving you a second chance.
2. Increased Healing from Fonts: Boosts the health recovered from healing fonts found between encounters. This reduces your reliance on luck-based Gluttony perks for sustain.
3. Bonus Reroll Token: Grants you an extra opportunity to reroll the selection of Boons you're offered. This gives you more control over your build and helps you find those key synergies.
4. Chance for Higher Rarity Boons: A permanent, passive increase to the chance of finding Rare, Epic, and eventually Heroic perks. This is a long-term investment that dramatically increases the power ceiling of your runs.

06

FAQ: Your Perk Questions Answeredtag

How do I get Heroic perks?tag

Heroic perks are the rarest in the game. They are typically offered only after you have acquired several other Boons from the same god in a single run, creating a prerequisite synergy. Some Ascension Perks can also increase their appearance rate.

Should I sell perks I don't want?tag

Yes. At Charon's shops, you'll sometimes have the option to sell a Boon for gold. It's often worth selling a low-impact Common perk to afford a more powerful one or a crucial health top-up before a boss fight.

What's the best way to re-roll perks?tag

You are given a limited number of re-roll tokens per run. Save them for critical moments when none of the three Boons offered fit your build. Don't waste them early on trying to find a perfect Common perk; use them later when you're looking for that final Epic or Heroic piece of your build.

Can you stack the same perk?tag

No, you cannot acquire the exact same Boon twice. However, you can acquire multiple different Boons from the same category (e.g., two different Wrath perks) and their effects will stack, allowing you to heavily specialize in a single strategy like critical damage.

07

The Final Judgmenttag

Mastering the perk system in 33 Immortals is a journey of trial and error, but the core philosophy remains constant: synergy is everything. A build with five S-tier perks that don't interact will always be weaker than a build with five B-tier perks that amplify one another. Focus on a core strategy—be it critical hits, DoT, or on-hit effects—and dedicate your Boon choices to enhancing that single goal. Do that, and you'll be leading the charge against Lucifer in no time.